Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide
نویسندگان
چکیده
منابع مشابه
Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide.
OBJECTIVES By adapting an antibiotic-susceptible Staphylococcus aureus strain to increasing concentrations of ethidium bromide, a known substrate of efflux pumps (EPs), and by phenotypically and genotypically analysing the resulting progeny, we characterized the molecular mechanisms of S. aureus adaptation to ethidium bromide. METHODS S. aureus ATCC 25923 was grown in increasing concentration...
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BACKGROUND Efflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the effectiveness of antimicrobial therapy. The development of methods for the early detection and quantification of drug transport across the bacterial cell wall is a tool essential to understand and overcome this type of drug resistance mechanism. This approach was developed to s...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2008
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkn217